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Some of the most potent oils contain up to 12,000 milligrams (mg) of cannabidiol (CBD) per 30 milliliters (mL). We look at nine of the best potent options and provide hands-on reviews for oils from FAB CBD and Nuleaf Naturals.

Is CBD legal?The 2018 Farm Bill removed hemp from the legal definition of marijuana in the Controlled Substances Act. This made some hemp-derived CBD products with less than 0.3% THC federally legal. However, CBD products containing more than 0.3% THC still fall under the legal definition of marijuana, making them federally illegal but legal under some state laws. Be sure to check state laws, especially when traveling. Also, keep in mind that the FDA has not approved nonprescription CBD products, and some products may be inaccurately labeled.

Medical News Today chooses strong CBD oils that meet the following criteria:

  • Ingredients: Products must contain safe and high quality clearly labeled ingredients. They should also confirm they are free from pesticides, heavy metals, and mold.
  • Dosage: Products that must clearly state the CBD dosage. MNT only features products that have safe CBD dosages.
  • Serving size: Manufacturers should clearly recommend a dosage.
  • Third-party labs: Products must undergo third-party testing for contaminants in an ISO 17025-compliant laboratory.
  • Available certificate of analysis: We choose companies that demonstrate transparency and share a product’s certificate of analysis (COA) after receiving its third-party lab results.

Medical News Today follows a strict product selection and vetting process. Learn more here.

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Below are some examples of high-strength CBD oils and tinctures.

Please note that this article’s writer has not tried these products, and all the information presented is research-based. All the products tested below were tried by Healthline writers or editors, who received the oils for free. All opinions are their own.

The table below provides a quick comparison of the strongest CBD oils in this article:

PriceSizeDosage per bottleDosage per serving
Zatural$27.50–$3601, 2, and 4 fl oz12,000 mg100 mg
CBDMD$89.99–$209.991 fl oz7,500 mg250 mg
Spruce$2691 oz2,400 mg80 mg
NuLeaf$19–$2490.17 to 3.38 fl oz300–6,000 mg30 mg
Lazarus Naturals$40–$12030 or 120 mL1,500 mg or 6000 mg50 mg
Charlotte’s Web$199.9930 or 100 mL1,800 mg or 6000 mg60 mg
Cornbread$39.99–$74.961 fl oz375, 750, or 1,500 mg25 or 50 mg
Medterra$39.99–$199.991 fl oz500, 1,000, 3,000, or 6,000 mg16, 33, or 100 mg
FAB CBD$1291 fl oz2,400 mg20 mg

A person interested in trying CBD oil should research different products to find one that is safe and reliable. Customer reviews from third-party sites, such as the Better Business Bureau and Trustpilot, are useful tools when researching brands.

Individuals may want to review each product’s ingredient list and concentration levels. They might want to know if the product is lab-grade and third-party tested.

A person using CBD for the first time may find a product with a lower dosage more suitable. They can then gradually increase the dosage as desired.

Read our complete CBD buyer’s guide or learn how to buy the best CBD oil.

According to research, CBD can negatively interact with medications, such as anticonvulsants, including diazepam, lamotrigine, and phenytoin.

People should also not use CBD alongside sedative drugs, such as barbiturates, and narcotics, such as codeine and morphine. Anybody taking medication should speak with a qualified healthcare professional prior to taking CBD.

CBD can make people drowsy, so people should avoid driving and handling heavy machinery when taking this product.

A person taking CBD for the first time should avoid strong CBD. It is better to start with a lower dose and increase the dosage slowly.

A person should always speak with a healthcare professional before using CBD products.

While there is a wealth of research regarding the effects of cannabis and THC, few high quality human trials are investigating CBD alone.

It is difficult for experts to predict precisely how differences in strength affect CBD’s effectiveness.

Based on the findings of a 2020 review, CBD appears relatively safe at various doses. However, the authors did not pinpoint a specific dose or range of doses they believed would benefit everyone.

Most of the studies included in this review evaluated daily doses of 300–600 mg of CBD, but a few studies reported using doses as high as 2,000 mg per day.

Everyone responds differently to CBD, so it is best for people using CBD for the first time to start at a lower dose.

Purchasing a higher CBD concentration product may be more cost-effective and convenient for some people.

For example, someone who uses 300 mg of CBD for chronic pain or anxiety would use 12 full droppers of 25 mg of CBD oil. They could get a similar 300 mg dose by using only one and a half droppers of 2,000 mg CBD oil.

However, stronger products may provide more CBD per unit but may lead to inaccurate dosing.

Learn more about CBD dosage.

CBD does not appear to cause any significant side effects, even at doses above 150 mg per kilogram (kg) of body weight.

However, the Food and Drug Administration (FDA) warns that using CBD products may produce the following adverse effects:

  • drowsiness
  • gastrointestinal problems
  • diarrhea
  • decreased appetite
  • mood changes, such as irritability
  • liver injury (with certain drug interactions)
  • interactions with alcohol and other drugs

The FDA has approved only one CBD product, called Epidiolex, which is for severe forms of childhood epilepsy. The FDA does not regulate any other CBD products.

Learn more about the side effects of CBD.

Label accuracy

People should avoid purchasing products from companies that have inaccurate labeling. The FDA has a database of CBD companies to which it has issued warnings, as the content did not match the amount of CBD on the product’s labels.

In a recent study, researchers found that nearly half of the 80 CBD products it looked at that were available for sale in central Kentucky had inaccurate label information.

However, most reputable CBD manufacturers will provide third-party lab results to their customers.

People should always use caution when shopping for CBD, especially high-potency products. High-potency CBD products can be inaccurately labeled. Some products may not even contain CBD.

Additionally, some CBD products may contain enough THC to produce a positive result in a drug test.

Learn more about THC and drug tests.

A person should always speak with a healthcare professional before trying any supplement, including CBD oil, especially if they are currently taking medication. If they are considering taking CBD for a particular health problem, such as sleep issues, anxiety, or pain, they should speak with a doctor to make sure it is a suitable supplement to try.

If they experience side effects after taking CBD, they should stop using it and contact a doctor.

Below are some of the most commonly asked questions about strong CBD oils.

Which CBD is most potent?

Full-spectrum CBD oil is likely to be the most potent type as it contains the full range of cannabinoids.

One of the strongest levels of CBD on the market in the U.S. is 12,000 mg per 30 mL. This features in a Zatural CBD oil.

Is there a 5,000 mg CBD oil?

Yes, people can buy 5,000 mg CBD oil in the U.S. Level Select and CBDistillery sell 5,000 mg CBD oils.

Is 1,000 mg CBD oil strong?

1,000 mg CBD is a moderate to high dose of CBD.

What is 40% CBD oil?

40% CBD oil means that 40% of a product’s total volume is CBD. The remaining 60% can comprise other cannabinoids, terpenes, carrier oils, and other ingredients.

Is 5,000 mg CBD strong?

Yes, 5,000 mg CBD is a strong dose. People should take this dose as the manufacturer directs. It is unlikely to be suitable for those new to using CBD.

Is 3,000 mg CBD oil strong?

Yes, 3,000 mg CBD is a strong dose. It is unlikely to be suitable for people new to using CBD.

CBD oil is a popular product with many potential benefits. However, more high quality, controlled trials are necessary to verify the medical applications of CBD.

People who currently use CBD products but feel they may benefit from stronger alternatives can use this article for guidance. Those who have never used CBD but are interested in trying it should start with a low dose and gradually work up to more potent products.

People should also discuss CBD with a doctor, as it might interact with medications and supplements.